EXPLANATION
Using a software restriction Policy you can create a
whitelist or blacklist policy of locations that software is allowed to
launch from. This included applications, scripts and so on. You can
easily block software from launching from anywhere within a users
profile, including the downloads folder. If you want to get into the
advanced settings, you can blacklist ALL software and provide a while
list of hashes for applications on your domain. SRP is extremely
powerful, and very user friendly to configure. It is a valuable tool to
use in keeping your network safe.
SOURCE
https://technet.microsoft.com/en-us/library/cc786941(v=ws.10).aspx
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